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RNAi application: Genetic dissection of mammalian host-pathogen interactions
The talk is free and open to public. Wonder how does an injected double-stranded RNA turn down the gene expression in C. Elegans with a homologous nucleotide sequence? This RNA interference (RNAi) phenomenon has been recognized as an important cell mechanism in protecting genome by turning down specific genes at critical times. It is also an exciting new tool for probing how genes work and for treating diseases. Dr. Lu's talk will provide a general overview of RNAi technology and focus on his research work on the developement of a novel gene inactivation system based on the expression of anti-sense expressed sequence tags. He will show how this system can be applied to dissect the interactions between mammalian host and diverse pathogens. In particular, he will discuss the study that identified the co-receptor for anthrax toxin as well as the work on host involvement in the release of the HIV virus. Dr. Lu is currently a researcher in Prof. Stanley Cohen's lab. He has accepted the offer to start a tenure track position at Harvard University this fall.
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